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While high doses of these compounds sometimes produce a release of growth hormone from the pituitary gland, the effect is small

Following that, a phase I trial in children undergoing heart surgery showed the procedure to be feasible and safe (146)

Patients on a maximum dose of semaglutide lost 80% fat mass and only 20% lean mass

Heart Rate Acceleration With GLP-1 Receptor Agonists in Type 2 Diabetes Patients: An Acute and 12-Week Randomised, Double-Blind, Placebo-Controlled Trial

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The side effect profile is dose-dependent, predictable, and in most cases manageable with proper preparation