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By activating the GLP-1 and GIP receptors, it helps regulate insulin secretion and promotes a feeling of satiety in biological models

Both carry the same warnings for pancreatitis, gallbladder problems, and kidney injury from getting dehydrated, and both flag low blood sugar if you pair them with insulin or a sulfonylurea diabetes drug

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When activated with GLP-1r, GIP seems to potentiate not only the weight loss mechanism of the incretin but also the glucose lowering effects [13]

Stay well-hydrated, as dehydration can worsen cold sensitivity and make regulation more difficult

It is derived from a protective protein naturally found in human gastric juice