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Too much or too long use can alter ovarian or testicular signaling and menstrual cycles

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PCR was used to generate LRP1-1(amino acids 1-1182)-Flag, LRP1-2(amino acids 11832473)-Flag, LRP1-3(amino acids 24743284)-Flag, LRP1-4(amino acids 32853872)-Flag, LRP1-5(amino acids 38734544)-Flag, Strep-LRP1-C(amino acids 24743872), ECM1-1(amino acids 1-177)-HA, ECM1-2(amino acids 178432)-HA, ECM1-3(amino acids 433540)-HA, and ECM1-full length based on pcDNA3.1-LRP1-Flag and pCDH-ECM1-HA backbone respectively

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They stressed that the findings are observational at this stage we cant say for certain from these data that the use of GLP-1RAs alone was directly responsible for any of the health outcomes