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Within months, prescriptions for GLP-1 receptor agonists began growing at a rate that no demand model had projected, no supply chain had been designed for, and no CDMO capacity planning exercise had anticipated

Treatment should begin immediately without waiting for laboratory confirmation, since delays can result in irreversible neurologic injury

As GLP-1 has been implicated as a mediator in the putative gutrenal axis (a rapid-acting feed-forward loop that regulates postprandial fluid and electrolyte homeostasis), direct actions on the kidney have been proposed

Conversely, participants who had used liraglutide and maintained a regular exercise routine after discontinuing the drug regained only 2.5kg