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69 DNA damage mediates ataxia telangiectasia mutated activity and reduces SIRT1 deacetylase activity by disrupting the LARP7-SIRT1 interaction, thereby accelerating cell senescence

The peptides ability to cross the blood-brain barrier opens possibilities for central nervous system applications

It also plays a critical role in maintaining mitochondrial membrane integrity, protecting against lipotoxicity, and supporting mitochondrial quality control mechanisms

Andreeff M , Ling X, Shi YX, Spaeth E, Watson K, Battula VL, Lang F, Hortobagyi G, Marini F