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Other metal chelating proteins also include transferrin and serum albumin, which play a key role in indirect antioxidant defence by sequestering free metal ions such as Fe 2 and Cu 2 , preventing their participation in redox reactions that generate highly reactive species such as hydroxyl radical ( OH) [22]
The association between GLP-1RA treatments and thyroid cancer has been a topic of discussion since their early development with the understanding that GLP-1 receptors are present on rodent thyroid parafollicular cells (C-cells), and that GLP-1RAs can cause an increase in calcitonin, and both C-cell hyperplasia and medullary thyroid carcinoma (MTC)
doi: Saunders, B., Elliott-Sale, K., Artioli, G
Williams LM (2012) Hypothalamic dysfunction in obesity
J Clin Endocrinol Metab 93: 310314