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Many patients find it helpful to anchor their injection to a memorable daily routinesuch as after breakfast or before bedrather than a specific clock time, which simplifies time zone transitions

Cecilia Low Wang, endocrinologist at UCHealth and professor at University of Colorado School of Medicine, tells TODAY.com

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To start, 28 healthy volunteers who had never taken a psychedelic were given 1mg of psilocybin, a small enough dose to be considered a placebo

Vorhees CV, Williams MT

That said, some providers do recommend stepping down the dose gradually rather than stopping all at once, and there are practical reasons for this approach