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Berberine is generally well-tolerated at typical doses but can cause gastrointestinal effects like nausea, constipation, or diarrhea in some people

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In the SUSTAIN 6 trial of subcutaneous once weekly semaglutide, more retinopathy events occurred in the semaglutide group

2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency