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Results for Phase II Clinical Trial of LCL161, a SMAC Mimetic, in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (post-PV MF) or Post-Essential Thrombocytosis Myelofibrosis (post-ET MF)

Within minutes of the infusion, the patients reportedly experienced nausea, vomiting, lightheadedness, chills, body aches and sneezing

The HTML:TML ratio was decreased by IDH1 inhibition and rescued by KG (Extended Data Fig

cDNA was prepared from total RNA and used for gene expression by real-time quantitative RTPCR (qPCR) as described [53] using TaqMan Gene Expression Assays (ThermoFischer Scientific) specific for human GCLC (Hs00155249_m1), OCT4 (Hs00999632_g1), and ACTB (Hs01060665_g1)

What is Interstitial Cystitis

Sometimes used off-label for weight loss