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Additionally, the metabolism of dopamine by monoamine oxidase (MAO) produces hydrogen peroxide (H 2 O 2 ), which can be converted to highly reactive hydroxyl radicals via Fenton reactions in the presence of transition metals [160]

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This increase was weaker than that observed with fdx-2 or lias-1 knockdown in wild-type and slcr-46.1 mutant worms, indicating that partial loss of copper transport or binding capacity alone is insufficient to suppress cuproptosis

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