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The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA

and M2 macrophages (M2) uses the effective coupling of respiration in the electron transport chain to enhance oxidative phosphorylation (OXPHOS), reduces ROS production, and promotes improved obesity and systemic glucose homeostasis by inhibiting adipocytes proliferation (136, 137)

Zhou F, Li C, Zhang SY