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Cost and Commitment Considerations Adding TB-500 increases both cost and complexity of the protocol

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Step 1: concentration Concentration is total peptide mass divided by diluent volume: 5 mg vial 3 mL = 1.667 mg/mL = 1,667 mcg/mL 10 mg vial 3 mL = 3.333 mg/mL = 3,333 mcg/mL Step 2: volume for a target amount Volume equals target dose divided by concentration

Participants clinical data will be anonymised, following an approved internal process, before data are shared to external third parties