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Diet-induced obese animals exhibit indices of altered central monoaminergic neurotransmission, including reduced hypothalamic 1 adrenoceptor binding, enhanced electrophysiological responsiveness to norepinephrine application, decreased basal hypothalamic serotonin and dopamine levels, and reduced mesolimbic dopamine activity

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Ozempic and Rybelsus are used off-label for weight management

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