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doi: 10.1016/j.tins.2013.10.003 26 KennedyGSpenceVAMcLarenMHillAUnderwoodCBelchJJ

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By inhibiting the binding of PCSK9 to LDLR, evolocumab increases the number of LDLRs available to clear LDL from the blood, thereby lowering LDL-C levels

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