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McGuire DK, Shih WJ, Cosentino F, Charbonnel B, Cherney DZI, Dagogo-Jack S, Pratley R, Greenberg M, Wang S, Huyck S, Gantz I, Terra SG, Masiukiewicz U, Cannon CP
Implications for disease phenotypes
This pattern repeats with each dose increase, which is why slow titrationbeginning at low doses and increasing graduallyremains the clinical gold standard for maximizing tolerance
However, concerns are emerging related to the potential loss of muscle mass linked to these treatments, with significant implications for long-term health, as came out of a recent editorial in the prestigious journal The Lancet entitled Muscle matters: the effects of medically induced weight loss on skeletal muscle, which underlined how GLP-1 receptor agonists have revolutionized the treatment of obesity and proven to be effective in reducing body weight
GLP-1 also stimulates nerve fibers in your gut, triggering gut-brain communication that helps to quell hunger