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For instance, many AD patients display behavioral symptoms such as rest-activity rhythm fragmentation [176], sundowning (characterized by recurring confusion or agitation in the late afternoon or early evening) [177], and disturbances in sleep and wake maintenance [178]

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During the trial, the liraglutide injection and metformin doses were fixed, although glimepiride and insulin glargine doses could be adjusted

[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, et al