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The levels needed to produce these fetal effects approach or equal the dose needed to produce maternal toxicity (section 7.6)

J Med Chem 38:272276 Pothula SP, Xu Z, Goldstein D, Pirola RC, Wilson JS, Apte MV (2016) Key role of pancreatic stellate cells in pancreatic cancer

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When this conversion is impaired due to reduced methylfolate, homocysteine accumulates in the blood, causing inflammation and oxidative stress in blood vessels

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