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& De Meijer, V
GLP-1 has a variety of physiological functions, which can regulate blood glucose level by promoting insulin secretion and synthesis, stimulating -cell proliferation and inducing islet regeneration, inhibiting -cell apoptosis and glucagon release, delaying gastric emptying and controlling appetite (Mller et al., 2019
Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)
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