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In Phase I, the liver breaks down fat-soluble toxins into smaller, often more reactive intermediate molecules

Cells, 13(18), 1545.

Echinatin, a chalcone isolated from the Chinese herb licorice, possesses anti-inflammatory and antioxidant properties

Moreover, inflammatory cytokines have been found to disrupt iron homeostasis in chondrocytes by upregulating transferrin receptor 1 (TfR1) and downregulating the iron transporter ferroportin (FPN), contributing to iron overload (Jing et al., 2020)

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