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Data availability The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request

Numerous animal models have shown that the peptide stimulates cartilage regeneration while pushing inflammation down

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[20, 39] The eGFR (or serum creatinine) is a useful biomarker for assessing kidney function and the UACR and eGFR should be measured together, particularly for staging CKD [6, 18]

Not only that, the nanoparticle vaccine R848-GA@TCLs based on sulfite-modified Toll-like receptor 7/8 (TLR7/8) agonist R848, can promote the production of pro-inflammatory cytokines, activate DCs, and significantly increase the number of effector T cells, NK cells, and M1 TAMs, markedly inhibiting tumor growth and metastasis in various tumor models (218)