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A: Milk Thistle (Silymarin) and Alpha Lipoic Acid work synergistically with glutathione to recycle antioxidants, enhance liver detoxification and amplify free-radical neutralizing effects
SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-R-H): role of Fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in COVID-19 control
Plant Mol Biol 28:113122
Moreover, iPLA2, a member of the calcium-independent phospholipase A2 family, functions independently of glutathione by cleaving oxidized fatty acid chains from phospholipids, directly removing peroxidized products, effectively detoxifying damaged lipids, and maintaining membrane integrity (Chen et al., 2021)
Glutathione is a tripeptide made up of three essential amino acids: Glutamine Cysteine Glycine Produced primarily in the liver , glutathione serves as a natural detoxifier that neutralizes harmful free radicals, supports cellular repair, and enhances metabolic function
These modifications alter chromatin accessibility and transcriptional activity 29
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