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The culprits are two compounds, cafestol and kahweol, which are found in the fines of the coffee grounds, tiny particles that get trapped in the paper filter

Animals were housed five per cage with ad libitum access to water and chow (Shanghai Slac Laboratory Animal Co., Ltd, P1300F-25)

Neuroscience 137:80719, PMID: 16330153 Abramov AY, Canevari L, Duchen MR (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity

Experiments with fasted and calorie-restricted rats showed increased mRNA concentrations of acyl-CoA and CPT-1 in the liver, heart and kidneys compared to control animals due to upregulation of PPAR [111]

2023 Mar;29(3):551-561

It has been touted as a miracle drug for its on- and off-label uses