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However, poor eating habits, smoking, stress, a sedentary lifestyle, lack of hydration and excessive drinking lead to a deficiency of important nutrients

Google Patents

Biomaterials 83 , 156168 (2016)

Despite that UPR helps cells to cope with ER stress, prolonged ER stress induces apoptotic cell death where the accumulation of unfolded protein in ER results in increased expression activating transcription factor 4 (ATF-4) that in turn increases the transcription of the proapoptotic protein, C/EPB-homologous protein-10 (CHOP-10) (Li et al., 2014)

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Tian et al., 2024)