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And FOXO4-DRI selectively induced apoptosis of senescent keloid cells at the same clearance efficiency as in normal skin fibroblasts

Existence of genetic variants of thiamine-dependent proteins, insufficient molecular identification of these proteins, as well as the age- and sex-dependent differences in thiamine metabolism (30), may contribute to the observed variety of clinical manifestations of thiamine deficiency (31, 32)

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Janumet also comes in an extended-release formula called Janumet XR