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Curr Protoc Bioinf (2016) 2016:14.10.1114.10.91

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Participants were asked, "Have you ever had symptoms of a bladder infection (such as pain in your bladder and frequent urination) that lasted more than 3 months?" Those who gave a positive response were then asked, "When you had this condition, were you told that you had interstitial cystitis or painful bladder syndrome?" An affirmative answer to both questions was considered to define the presence of IC/BPS

In addition, a phenocopy may appear in the family, which means a person with similar clinical features of the disease caused by some unknown environmental factors or by a different genetic mechanism (Klein and Westenberger, 2012)

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However, its universal effectiveness lacks comprehensive scientific validation