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The DCCT participants were followed in an observational Epidemiology of Diabetes Interventions and Complications (EDIC) study

Hormonal balance affects weight loss

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Cyclin D1 is a key protein in cell proliferation and initiates DNA synthesis (Figure 2A) by promoting the cell cycle (Figures 2B, C) and upregulating cyclin D1, CDK2, and CDK4 (Figure 2D)

The mTOR pathway, closely linked to mitochondrial function, may drive increased fatty acid content, with the IL-17 pathway linking lipid metabolism and the accumulation of lipid droplets [63, 143]

Combinada con entrenamiento y una dieta adecuada ayuda a que el cuerpo use ms grasa como combustible