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Am J Physiol 271:R848R856 [DOI] [PubMed] [Google Scholar] Hayes MR, Skibicka KP, Grill HJ 2008 Caudal brainstem processing is sufficient for behavioral, sympathetic and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation

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In the SUSTAIN-6 trial (cardiovascular outcomes in type 2 diabetes), headache was reported in approximately 8% of semaglutide-treated participants, compared to 6% in the placebo group, suggesting a modest excess risk rather than a dominant issue

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