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TSTU (24.78 gm) and DIPEA (18.87 ml) were added to the reaction mixture at 25-30C and stirred for 2 hr at the same temperature to get the title compound

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Studies suggest a role for brain-derived GLP-1 in the control of eating and reward (80, 81), but there is no evidence that peripherally administered GLP-1RAs can directly access GLP-1Rs in these regions, as demonstrated by the lack of fluorescently labeled semaglutide in these brain nuclei

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Early referral to rheumatology is essential for prompt diagnosis and treatment to prevent joint damage