Advantage : Neither (tie) Weight Loss Efficacy# Orforglipron : ATTAIN-1 demonstrated 12.4% mean weight loss at 36 mg over 72 weeks (efficacy estimand)
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A cohort study showed that the GLP-1RA group had a higher bile duct cancer reporting rate than sulfonylurea (ROR: 1.63, 95% CI 1.002.66) and thiazolidinedione (ROR: 4.73, 95% CI 2.957.58) groups (Ueda et al., 2021)
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In the STEP UP trial, adults living with obesity who received semaglutide 7.2mg achieved an average weight loss of 18.7% over 72 weeks, compared with 15.6% with 2.4mg and 3.9% with placebo
Eric Levin, CEO Apr 9, 2025 4 min read In the world of chronic disease and weight management, few breakthroughs have generated as much excitementor delivered as much promiseas GLP1-s