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Vesicular and nanocarriers The drug-carrying vesicles in transdermal delivery including liposomes and nanoparticles are one of the most promising methods which ease skin penetration as it improves fluidizing the skin lipids, the drug portioning into the skin, and drug solubilization into the formulations [289, 290]

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Since 2020, 8 of the 20 published clinical trials have focused on neurodevelopmental and neuropsychiatric/cognitive disorders, exhibiting a significant rise in clinical trials exploring sulforaphanes efficacy in the CNS compared to the previous two decades where only two of 57 trials focused on ASD alone with no published trials examining other CNS disorders (Supplementary Table 1)

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