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Efficacy and safety of once-weekly efpeglenatide monotherapy versus placebo in type 2 diabetes: the AMPLITUDE-M randomized controlled trial

Liraglutide exerts protective effects by downregulation of PPAR, ACSL1 and SREBP-1c in Huh7 cell culture models of non-alcoholic steatosis and drug-induced steatosis

Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

Mechanism of Action Incretins hormones like GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are released throughout the day, increasing at mealtimes

doi: 10.1016/S0140-6736(15)00803-X 202 NewsomePNBuchholtzKCusiKLinderMOkanoueTRatziuVet al

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