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In addition, Ganshuang Granules [composed of Chinese herbs such as Radix Codonopsis, Bupleurum Falcatum and Salviae Miltiorrhiza] can rebalance the gut microbiota and reduce intestinal permeability, thereby reducing oxidative stress and inflammation and ultimately ameliorating CCl 4 -induced hepatotoxicity and ALI (49)

This metabolism offers benefits such as (i) reduction of NAD+ to NADH, essential for several enzymes, and (ii) supply of nucleotide intermediates (PPP), serine biosynthesis, and de novo lipogenesis