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Recently, Takeda and colleagues reported that mutant HSC70 nominally beneficial for modifying the SOD1ALS phenotypeparadoxically exacerbated symptoms in mice despite reducing SOD1 content (Takeda et al., 2025)

Glutathione is a potent antioxidant that plays a crucial role in protecting cells from damage caused by harmful free radicals

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However, there is still a lack of evidence that PINK1/Parkin mediates mitophagy in vivo

Stein GE, Wells EM