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Interestingly, GAMT activity was not detected in the head kidneys or proximal intestine in all groups of Phase-II HSB

Dooley HC, Wilson MI, Tooze SA

Both the IGB only group and the IGB + semaglutide group achieved the most substantial weight reduction during the first six months, aligning with the established therapeutic window for IGB therapy [14]

The slower movement of food from the stomach to the small intestine may delay the absorption of certain nutrients, such as carbohydrates and triglycerides

Studies have also reported modest effects on energy expenditure

Taken together, these studies indicate that inducing ferroptosis in HSCs may represent a viable strategy for treating and/or preventing liver fibrosis