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It was tested in series of eight global and two Japanese phase-3 studies encompassing the continuum of treatment in type 2 diabetes mellitus, ranging from patients managed with diet and exercise only (drug-nave), through to people already taking one or more, other anti-diabetic medications, those who require insulin, and in patients where cardiovascular and renal safety are concerns (Avgerinos et al., 2020
(4) Potential mechanisms may involve reduction of NF-B and MAP kinase signaling, and interactions with vasodilators like nitric oxide (NO), thereby possibly lowering pro-inflammatory cytokine output
Certain medications, such as those used for pain management, sedatives, and some antidepressants, may have fatigue as a side effect
Griffiths L
