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Clinical Evidence: Heart Attack and Stroke Risk Reduction The SUSTAIN-6 trial, which followed over 3,000 people with type 2 diabetes and existing heart disease or high cardiovascular risk, found that semaglutide reduced the combined risk of heart attack, stroke, and cardiovascular death by 26% compared to placebo

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Moreover, some of the impressive metabolic gains from bariatric surgeries have been ascribed to alterations in the secretory profile of gut hormones