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The rising global prevalence of T2DM and obesity makes understanding the full range of benefits and risks associated with GLP-1 RAs essential for optimizing treatment strategies in these populations

Nat Struct Mol Biol (2014) 21(5):4438.10.1038/nsmb.2807 72 McNallyREckMJ

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On the other hand a GLP1-ANP axis has been only demonstrated in hypertensive mice, in which GLP-1R activation in the atria leads to ANP secretion and stimulation of natriuresis and vasodilation in the consequence

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PMID 2185014