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Neutrophils are believed to be the main source of ROS/RNS [69] and their production is catalyzed by NADPH oxidase on the cell membrane [59]

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Sublingual delivery can in principle bypass first-pass hepatic metabolism by absorbing through the oral mucosa directly into systemic circulation

Their half-lives are comparable (a few minutes in the periphery, prolonged action in the central nervous system)

Very recently a new map of G6PD deficiency in malaria-endemic areas has been produced