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Additionally, there is evidence indicating that enhanced pro-inflammatory cytokine signalling may promote ROS generation and lead to oxidative damage which is schematized in ( Figure 6 )

Zahs, A

Is Accutane safe for someone with eczema or very dry skin

proposed that we could regard the activation of NLRPs as an upstream step in the IL-1R and IL-18R signaling cascades due to their capacity to recruit MyD88 involving NF-B and thus directly linked intracellular pathogen recognition to signaling pathways shared with TLRs (42)

But always patch test especially if you have sensitive skin, use other active treatments (acids, retinoids), or have skin conditions (eczema, rosacea)

That distinction matters