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Interestingly, glucose intolerance could be improved when IGF-1 was systemically administered

DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice

For example, while enhanced expression of Nrf2 can reduce ROS levels and decrease stress responses (Suzuki et al., 2013), the activation of Nrf2 minimizes cancer cell sensitivity to conventional cancer treatments (e.g., chemotherapy and radiation) (DeNicola et al., 2011)