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Long-term levodopa treatment, while effective in alleviating motor symptoms, has been associated with increased oxidative stress and the generation of toxic metabolites, which can accelerate the loss of dopaminergic neurons

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Data were log 10 transformed and autocorrected by subtracting the mean and dividing by the standard deviation

3a), which is well consistent with the tendency of transcriptome data from plants in response to wounding, namely, more transcripts are upregulated than downregulated 27,28

In this group, the hepatic secretion of biliary bile acids and the solubilization of cholesterol in bile are greatly reduced, another factor associated to supersaturated bile [7]