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Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland Abstract Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria, peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure, xenobiotic compounds, and cigarette smoke)

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Among ROS, hydroxyl radicals are particularly harmful, causing mitochondrial dysfunction and contributing to conditions such as cancer, Parkinsons disease, dementia, and skin aging

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When oxidative stress exceeds the liver's protective capacity, cellular damage accumulates, potentially leading to inflammation, fibrosis, and impaired liver function