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eLife 2014;3:e02523

In experiments with hFOB1.19 cells, MOTS-c treatment increased cell viability in a time-dependent manner and upregulated mRNA and protein expressions of TGF-, SMAD7, COL1A1, and COL1A2

The investigators first determined the presence of GLP-1R in mature oligodendrocyte cells in the CNS

The buildout is driven by GLP-1 agonist commercial demand, which has created persistent API supply constraints, and by a broadening clinical pipeline that includes GLP-1 combinations, cyclic peptides, peptide-drug conjugates, and peptide-oligonucleotide hybrids

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