Several case studies have reported the onset of mania and rapid-cycling bipolar disorder following cerebellar lesions caused by either surgery or trauma, which indicates a potential role for the cerebellum in the pathophysiology of bipolar disorder [110,111,112]
This triple agonism creates synergistic effects across central and peripheral pathways, influencing appetite regulation, energy expenditure, glucose homeostasis, lipid metabolism, and substrate utilization
Klionsky DJ, Petroni G, Amaravadi RK, et al
In the present study, low copper levels did not affect NFKB promoter activity in either HepG2 or HepG2 ATP7B-KO cells, despite increased NFKB-related cytokine levels in the culture medium
doi: 10.1016/0031-9384(93)90387-U 23 EckelLA
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