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Research using MC4R knockout mice and selective MC4R antagonists has established MC4R as the primary receptor mediating MT-IIs pro-erectile and pro-sexual effects with MC4R-null mice showing substantially reduced or absent MT-II-induced erections and sexual behaviour, and MC4R-selective antagonists blocking these responses at doses not affecting MT-IIs melanogenic activity

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Synergistic effects: SAMe may also exhibit synergistic effects when combined with other treatments, such as painkillers or antidepressants, which can enhance its therapeutic potential in FM management [69, 70]

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However, allow 4-6 weeks off for receptor resensitization