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Flanagan, J

Operates at the nuclear protein-interaction level: Unlike metabolic or hormonal peptides that act on membrane receptors, FOXO4-DRI functions by disrupting nuclear protein interactions

PMID 17018654)Tier 1 primary [8]FDA: Pharmacy Compounding Advisory Committee meeting (29 Oct 2024

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However, the new cartilage created by FOXO4-DRI pretreated PDL9 cells indeed displayed reduced expression of several SASP factors, implying the benefit of FOXO4-DRI pre-treatment in enhancing the cartilage quality