Enteric-coated capsules reduce but do not eliminate enzymatic degradation
10.1038/s41372-018-0101-3 90
Discussion The key findings from the two reported trials were that administration of oral semaglutide in the fed state resulted in limited semaglutide exposure, that semaglutide exposure increased with longer post-dose fasting periods, particularly from 15 to 30 min, and that semaglutide exposure was comparable when the oral semaglutide tablet was administered with 50 or 120 mL water
to solid products mainly consisting of alpha-form crystals, but with the simultaneous presence of beta- form crystals in percentages varying from batch to batch
This means people on these medications can struggle to drink enough water without realizing it, which can exacerbate side effects like nausea
Nakazaki, E., Mah, E., Sanoshy, K., Citrolo, D., & Watanabe, F