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These doses, of course, do not scale to human subjects

271,272,273,274,275 Mechanismly, various factors including the abnormal accumulation of -syn, microglial activation and neuroinflammation, 276 autophagic impairment, 277,278,279 mitochondrial, 280 and proteasomal dysfunction 281,282 are involved in the pathogenesis of MSA

It catches most individuals off guard

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Its now being investigated for potential longevity benefits and as a treatment for age-related macular degeneration