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It did not escalate with long-term use

In some embodiments, the otic formulation or composition comprises about 0.5% by weight of the viscosity modulating agent(s)

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Exposure to greater than 25 mg may precipitate a hypertensive crisis , marked by a rapid rise in blood pressure (often exceeding 180/120 mmHg), chest pain, and acute confusion

In general, adverse reactions in pediatric patients (including serious adverse reactions and adverse reactions leading to permanent discontinuation of CRESEMBA) were similar to those reported in adults