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As a result, the mechanisms underlying the impact of glucagon-like peptide-1 medications on the kidneys are unknown

SURPASS-1 (NCT03954834) was a 40-week double-blind trial that randomized 478 adult patients with type 2 diabetes mellitus with inadequate glycemic control with diet and exercise to subcutaneous MOUNJARO 5 mg, MOUNJARO 10 mg, MOUNJARO 15 mg, or placebo once weekly

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Related Reading Tirzepatide Vs Semaglutide Side Effects Why Do I Feel Tired After Eating Is It In My Genes Lifemd Tirzepatide Goodlife Meds Tirzepatide Pricing and availability current as of June 2026

Key Takeaways at a Glance Bottom line: Most GLP-1 fatigue is practical, not mysterious: appetite drops, intake shrinks, fluids/electrolytes slip, and GI side effects disrupt routines

J Immunol 159 : 4452 Mizoguchi E et al